Indications for hematopoietic cell transplantation for children with severe congenital neutropenia
نویسندگان
چکیده
منابع مشابه
Indications for hematopoietic cell transplantation for children with severe congenital neutropenia.
Severe congenital neutropenia (SCN) is a hematologic condition characterized by arrested maturation of myelopoiesis at the promyelocyte stage of development (1). With appropriate treatment using recombinant human granulocyte colony-stimulating factor (r-HuG-CSF), patients with SCN are now surviving well past infancy. With longer survival, the high risk of developing myelodysplastic syndrome (MD...
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Transplantation of hematopoietic stem cells derived from bone marrow or peripheral blood has been used as a therapeutic procedure since the mid-seventies. In recent years, the number of transplants reported annually to the European Group for Blood and Marrow Transplantation (EBMT) Registry is approximately 23,500 including 38% of allogeneic and 62% of autologous procedures. In most developed co...
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thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. for β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...
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ژورنال
عنوان ژورنال: Pediatric Transplantation
سال: 2010
ISSN: 1397-3142
DOI: 10.1111/j.1399-3046.2010.01386.x